Fluorescent Form also available. Learn more about Agile Diagnostics&x27;s work experience, education, connections & more by visiting their profile on LinkedIn. trans-ISRIB is a potent integrated stress response (ISR) inhibitor; reverses the effects of eIF2 phosphorylation (IC 50 5 nM) and restores cell. MDL 100907 is a potent and selective 5-HT 2A receptor antagonist (K 0. CNQX can be used to isolate GABA A receptor-mediated spontaneous inhibitory postsynaptic currents and. Preparing Stock Solutions for Allopregnanolone. Tocris offers the following scientific literature in this area to showcase our products. Selected citations for CCCP include Purnell (2014) Efavirenz induces neuronal autophagy and mitochondrial alterations. SR 95531 hydrobromide is a selective, competitive GABA A receptor antagonist and allosteric inhibitor (IC 50 200 nM). Tocris Bioscience is the leading supplier of novel and exclusive tools for laboratory research. The stock solution of saponin with the recommended final assay concentration was made in 50 mM HEPES bufer pH 7. Signal Transduction. 7 x 10 -3 g in 1 ml. The following data is based on the product molecular weight 786. Biological Activity for Isoproterenol hydrochloride. Citations are publications that use Tocris products. Citations are publications that use Tocris products. Find products for various targets, functions, and applications, such as GSK-3 inhibitor, retinol-binding protein ligand, Bcl-xL inhibitor, K 2P blocker, SUV420H1H2 inhibitor, and more. XAV 939 inhibits proliferation of the -catenin-dependent colon carcinoma cell line DLD-1. Hematopoietic progenitor. Find products for. 7151) 2. 29 nM), devoid of any partial agonism both in vitro and in vivo. AR-C 118925XX inhibits ATP- S-induced mucin secretion in bronchial epithelial cells (IC 50 1 M). Citations are publications that use Tocris products. Fluorescent Form also available. Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. Retinoic acid is an endogenous agonist for retinoic acid receptors (IC 50 14 nM for RAR , RAR and RAR receptors). Solvent Max Conc. Application of TSA Vivid dye 570 in RNAscope Multiplex Fluorescent v2 Assay RNAscope Multiplex Fluorescent v2 Assay on HeLa cells with the leading competitor dye (left) and TSA Vivid dye 570 (right). Also blocks I Cl,swell in various cardiovascular tissues (IC 50 4. Proc Natl Acad Sci U S A 8 444 PMID 25610372. The Tocris Scholarship Program has been established to award a 1,500 scholarship (or international currency equivalent) twice a year for the fall and spring semesters. A 485 suppresses proliferation in several hematological malignancies and AR prostate. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60MX2, keratinocytes, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines. Tocris Bioscience is the leading supplier of novel and exclusive tools for laboratory research. 3, 25, 26 and > 250 M for ROCK1 (p160 ROCK), ROCK2, PKA, PKC and MLCK respectively). These include Taxol Janelia Fluor 646 (Cat. Isoproterenol hydrochloride is a standard selective -adrenoceptor agonist; vasorelaxant and bronchodilator. Tocris Bioscience is the trading name of Tocris Cookson Ltd. If you know of a relevant reference for Glycine, please let us know. Solvent Max Conc. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK. Solubility Data for WS 12. References are publications that support the biological activity of the product. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand. TSA Vivid reagents are exceptionally bright dyes that offer an effective way to boost signal intensity and detect low-abundance targets in spatial biology applications. PD 168077 maleate is a potent D 4 dopamine receptor agonist (K 8. Displays selectivity for A 2B over A 1, A 2A and A 3 receptors. Alternative Names Dextroamphetamine sulfate. The following data is based on the product molecular weight 567. 1-Oleoyl lysophosphatidic acid sodium salt is an endogenous agonist of the lysophospholipid receptors LPA 1 and LPA 2. Tocris Bioscience is a life science company that offers a wide range of products for research and development. Has minimal activity against 24 other protein kinases (IC 50 > 10 M). Methoxy-X04 displays high in vitro binding affinity (K 26. Tocris is proud to support students who are pursuing a science related field of study (Life Science, Medical Science, Health Science). AGN 193109 promotes the differentiation from mouse embryonic stem cells into paraxial mesoderm. 60 M for PI 3-K , PI 3-K , PI 3-K and PI 3-K respectively). Here are examples from our range that we routinely synthesize. Tocris Bioscience is the leading supplier of novel and exclusive tools for laboratory research. AR-C 118925XX inhibits ATP- S-induced mucin secretion in bronchial epithelial cells (IC 50 1 M). Biological Activity for TCB-2. Biological Activity for Isoproterenol hydrochloride. Provides antithrombotic protection in. 4 and 20 nM for 5-HT 2A, 5-HT 2C and 5-HT 2B receptors respectively). Biological Activity for NSC 87877. NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. Inhibits cytopathogenic effect of SARS-CoV-2 and double-stranded RNA formation in SARS-CoV-2-infected cells. Simvastatin is also an AMPK activator. Spectra for other dyes are also included for reference purposes. PD 168077 maleate is a potent D 4 dopamine receptor agonist (K 8. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Binds within the ATP pocket of the active kinase (K d 38 nM, as measured in recombinant human p38), and selectively inhibits the p38 and isoforms (IC 50 50 and 100 nM at SAPK2ap38 and SAPK2bp38 2 respectively). 7 and 10 nM for GSK-3 and GSK-3 respectively). Baram et al (1997) The CRF 1 receptor mediates the excitatory actions of cortico. Tocris provides a range of fluorescent probes, including CoraFluor terbium cryptate FRET donors and fluorescent E3 ligase ligands, suitable for exploring ligand. There are approximately 50 employees in the company. Biological Activity for WY 14643. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo. 3 M and 1. Also an agonist at 5-HT 2C receptors in vitro (K values are 6. Dermal fibroblast cells were incubated with MitoBrilliant 646 (100 nM) for 1 hour at 37C, fixed with ice-cold acetone-methanol (11) and counterstained with Hoechst 33342 (Catalog 5117). Measure the absorbance at 450 nm using. Confocal excitation maximum 488 nm, emission maximum 495 - 595 nm. Tocris Products Alphabetically by Name. 7310), Polyamine Supplement x1000 (lyophilized) (Cat. Christian Soeller, University of Exeter; acquired by Alex Clowsley and Anna. dTAG is generalizable to a range of fusion proteins; useful as an alternative to genetic methods for target validation. We also produce in-house product guides, which give an overview of how our products are used in many research areas including stem cells , neuroscience and cancer ,. The following data is based on the product molecular weight 318. We work hard to understand your goals to ensure that they are met for. Browse products by alphabetical order of product name (A) from Tocris Bioscience, a leading provider of research chemicals and services. Exhibits antiviral activity against viruses from Coronaviridae family including SARS-CoV-2 in vitro, and SARS. Doxorubicin hydrochloride is a 14-hydroxylated version of Daunorubicin (Cat. Doxorubicin reduces intracellular tau levels. Preparing Stock Solutions for Carbamoylcholine chloride. Also an agonist at 5-HT 2C receptors in vitro (K values are 6. Biological Activity for NSC 87877. The following data is based on the product molecular weight 318. The Tocris custom sourcing team has spent many years developing relationships with hundreds of partner organisations that possess specialist skills and technical expertise. Biological Activity for TCB-2. Typically, polybrene is used at a concentration of 4 &181;gmL - 10 &181;gmL (see. In combination with 5 other compounds, forskolin enables chemical reprogramming of mouse embryonic fibroblasts to pluripotent stem cells, without genetic factors. Citations are publications that use Tocris products. Solvent Max Conc. Citations are publications that use Tocris products. Exhibits >50-fold selectivity for TBK1 over the closely related IKK. Fluorescent Dyes and Probes Research Product Guide. Biological Activity for SB 202190. Tyramide Signal Amplification (TSA) Tyramide Signal Amplification (TSA), also known as Catalyzed Reporter Deposition (CARD), offers an effective way to efficiently enhance signal and detection capabilities for low-abundance targets in immunocytochemistry (ICC), immunohistochemistry (IHC), and in situ hybridization (ISH) applications. Pladienolide B arrests the cell cycle in G 1 and G 2. 0190), which is an AMPA and kainate receptor antagonist (IC 50 values are 0. In germ cells from male mice, ()-JQ1 exhibits reversible contraceptive. Inhibits synaptic transmission at hippocampal CA1. Spectra for other dyes are also included for reference purposes. Induces apoptosis via p53-dependent and -independent mechanisms. 1 nM). Tunicamycin contains four main components as follows The composition of. Poly (IC) also promotes maturation of hPSC-derived cardiomyocytes by modulating early Notch signaling and cardiomyogenic transcriptional programs. WY 14643 is a selective PPAR agonist (EC 50 values are 0. SR 95531 displaces 3 H-GABA from rat brain membranes with a K of 150 nM. Induces an increase in axin2 protein levels; promotes -catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Fluoresces when bound to Pepper aptamer; displays high affinity binding (K d 3. Theranostics 10 12189-12203 PMID 33204337. L -Ascorbic acid is an inhibitor of Ca v 3. Abolishes renal protection induced by ischemic preconditioning. Save with limited-time price reductions across select products and categories. Solvent Max Conc. Keywords L-DOPA, L-DOPA supplier, dopamine, precursor, non-selective, receptors, parkinson's, parkinsons, Levodopa, Non-selective, Dopamine, 3788, Tocris Bioscience. Certificate of Analysis is currently unavailable on-line. There are approximately 50 employees in the company. Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. 1691) and adenosine (Cat. The following data is based on the product molecular weight 405. Has minimal activity against 24 other protein kinases (IC 50 > 10 M). NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo. Dynasore attenuates motor symptoms in an animal model of Parkinson's disease and in a cellular. The stock solution of saponin with the recommended final assay concentration was made in 50 mM HEPES bufer pH 7. The Tocris Scholarship Program has been established to award a 1,500 scholarship (or international currency equivalent) twice a year for the fall and spring semesters. 3 nM at D 1 and D 5 receptor sub-types, respectively). Useful resources to assist your research. (RS)- (Tetrazol-5-yl)glycine. The following data is based on the product molecular weight 307. Typically, polybrene is used at a concentration of 4 &181;gmL - 10 &181;gmL (see. North America. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. 3 nM, 4. NHS ester can be converted to relevant substrate for use in self-labeling tag systems, e. 23 1157 PMID 32632286. The Mass box will display an answer of 19. Step 3 Prepare Transfection Media. 930 M for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Signal transduction (also known as cell signaling) is the transmission of molecular signals from a cell's exterior to its interior. Potently stimulates IP 3 accumulation in NIH3T3 cells stably expressing rat 5-HT 2A receptors (EC 50 36 nM). In addition, we have a series of cancer posters adapted from the Cancer Product Guide, Edition 3. PEI is a synthetic polymer with an exceptionally high positive charge density in pH-neutral solutions. The following data is based on the product molecular weight 567. 73, 1. Janelia Fluor &174; 549, SE is a yellow fluorescent dye; supplied as an NHS ester for coupling to primary amine groups. The Bio-Techne molarity calculator allows you to calculate the mass of a compound required to prepare. Find contact details for all Bio-Techne daughter brands including R&D Systems, Novus Biologicals, Tocris, ACD, ProteinSimple, Asuragen, ExosomeDx and Namocell. GYKI 52466 dihydrochloride is a selective noncompetitive AMPA receptor antagonist (IC 50 values are 10-20, 450 and >50 M for AMPA-, kainate- and NMDA-induced responses respectively). Front Syst Neurosci 11 79 PMID 29109680. 275 864 PMID 7473178 Smith et al (2009) In vitro electrophysiological activity of nerispirdine,. AM 251 is a potent CB 1 receptor antagonist (IC 50 8 nM, K 7. Somatic instability is a phenomenon in which the expanded region of CAG repeats in the mHTT gene expands still further with time, as a result of faulty DNA repair. Exhibits no activity at phospholipase A 2, liver esterase, trypsin and chymotrypsin. Gordon (1986) Extracellular ATP effects, sources and fate. Learn more about the key dates and events of Tocris Bioscience&x27;s history and its products. Staurosporine inhibits cell viability and promotes apoptosis in oral and pancreatic cancer cells. Dermal fibroblast cells were incubated with MitoBrilliant 646 (100 nM) for 1 hour at 37C, fixed with ice-cold acetone-methanol (11) and counterstained with Hoechst 33342 (Catalog 5117). Citations are publications that use Tocris products. Preparing Stock Solutions for Allopregnanolone. 5, 9. Inhibits GABA B responses to baclofen (IC 50 130 nM in an isoproterenol. Torin 1 is a potent and selective ATP-competitive mTOR inhibitor (IC 50 2 - 10 nM for mTORC1 and mTORC2). Pladienolide B arrests the cell cycle in G 1 and G 2. Protocol available. 3097) sensitive manner. The following data is based on the product molecular weight 307. AMPA Receptors. Working with Scientists for More Than 35 Years. glucose) or macromolecules (e. Also reduces tau phopshorylation in cortical neurons at sites. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. I-BRD9 is a potent and selective BRD9 inhibitor (pIC 50 7. comfind-usdistributors TEL 1 612 379 2956. Reversibly inhibits currents through mouse, human and rat TRPV4 orthologs (IC 50 values are 17, 48 and 133 nM respectively). , HeLa Cells at 37&176;C, 5 CO2). A stoichiometry of (4)2 (2)3 has been proposed, generating two agonist binding sites consistent with the model of the muscle nAChR. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. DCPIB is a volume-regulated anion channel (VRAC) blocker (IC 50 2 M in rat pancreatic -cells). Biological Activity for 5-Fluorouracil. Biological Activity for L -Ascorbic acid. SB 415286 is a potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K 31 nM for GSK-3); competes with ATP. Calcipotriol is a vitamin D 3 analog that displays minimal effects on calcium homeostasis. Used in experiments to understand biological processes and diseases. It inhibits the transcription of STAT3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest. Biological Activity for TCB-2. 15 M and 4. Active Degraders. 06 and 6. We are an innovation-led contract research, development and manufacturing organization offering end-to-end solutions to fulfil R&D and manufacturing requirements of our clients. Contains compounds covering a diverse range of. IWP 2 suppresses self-renewal in R1 embryonic stem. 8 nM); binds selectively to fibrillar -sheet deposits. Biological Activity for Cabergoline. Induces potent and selective degradation of FKBP12 F36V fusion proteins in vitro and in vivo. Biological Activity for TSA Vivid Fluorophore Kit 520. Methoxy-X04 is a fluorescent amyloid (A) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Incubate the plate for 1-4 hours in the incubator. HaloTag &174; and SNAP-tag &174;. Fluorescein Tyramide is a green fluorescent reagent widely used for tyramide signal amplification (TSA) in IHC, ICC, FISH and multicolor FISH. 75 nM for rat and human receptors respectively). mgmL Max Conc. 71 75 Preparing Stock Solutions for WS 12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. PD 0325901 inhibits the growth of melanoma cell lines in vitro and in vivo; induces G 1 -phase cell cycle arrest and apoptosis in a mouse xenograft model. The following data is based on the product molecular weight 103. Tocris Bioscience is the leading supplier of novel and exclusive tools for laboratory research. 5 M for AMPA and kainate receptors, respectively). dTAG-13 is a degrader targeting mutant FKBP12 F36V fusion proteins. Selected citations for TTNPB include Thomas and Henry (2014) Retinoic acid regulation by CYP26 in vertebrate lens regeneration. Decreases fMLP-induced superoxide production in neutrophils. MZ 1 is a cell penetrant Degrader (PROTAC &174;) based on ()-JQ1 (Cat. Acceptors may be small organic molecules (e. 75 nM for rat and human receptors respectively). Methoxy-X04 is a derivative of Congo Red (Cat. Prevents the absorption of approximately one third of fat. A 83-01 is a potent inhibitor of TGF- type I receptor ALK5 kinase, type I activinnodal receptor ALK4 and type I nodal receptor ALK7 (IC 50 values are 12, 45 and 7. Photo-crosslinking probe for studying glycoproteins and glycolipids. Preparing Stock Solutions for (R)-ZINC 3573. C-Laurdan is a fluorescent probe for imaging lipid rafts. AR-C 118925XX is a potent, selective, competitive and reversible P2Y 2 receptor antagonist (pA 2 8. 1 nM). Spectra for other dyes are also included for reference purposes. Citations are publications that use Tocris products. For more details read Hsu et al (2017) Full color palette of fluorescent d-amino acids for in situ labeling of bacterial cell walls. Our highly skilled team has full control over the cGMP process, meaning we can ensure a quality-assured manufacturing system, batch-to-batch consistency, consistent supply, traceability from starting material to final product, and animal. 930 M for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Putative GPR35 ligand. The following data is based on the product molecular weight 318. Biological Activity for I-BRD9. The dTAG system, developed by Dr Behnam Nabet and colleagues at the Dana Farber Cancer Center, is a generalizable approach and a form of. Select a batch to recalculate based on the batch. Select a batch to recalculate based on the batch. A complete list of products in the Tocris Bioscience range listed alphabetically by Product Name A. 49 nM) that displays 306-fold selectivity over CB 2 receptors. The following data is based on the product molecular weight 336. 7163), Emricasan (Cat. Torin 1 impairs cell growth and proliferation by suppression of the rapamycin-resistant functions of mTORC1. 7310), Polyamine Supplement x1000 (lyophilized) (Cat. Solubility Data for WS 12. Insulin (human, recombinant, expressed in yeast) is an endogenous insulin receptor agonist (K 4. A 83-01 is a potent inhibitor of TGF- type I receptor ALK5 kinase, type I activinnodal receptor ALK4 and type I nodal receptor ALK7 (IC 50 values are 12, 45 and 7. 4, 1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. Biological Activity for L -Ascorbic acid. Biological Activity for SB 415286. Chemical Name ()- -Methylphenethylamine hemisulfate salt. dTAG V -1 is a degrader targeting mutant FKBP12 F36V fusion proteins. 0 and 165 nM for D 2, D 3, D 4 and D 5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (K i 1. Biological Activity for Tocriscreen FDA-Approved Drugs Library. 60 M for PI 3-K , PI 3-K , PI 3-K and PI 3-K respectively). Somatic instability is a phenomenon in which the expanded region of CAG repeats in the mHTT gene expands still further with time, as a result of faulty DNA repair. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service. The following data is based on the product molecular weight 318. 691, 7. Also an agonist at 5-HT 2C receptors in vitro (K values are 6. Clozapine is an atypical antipsychotic drug, with a much lower tendency to cause extrapyramidal side effects than conventional neuroleptics. Bio-Techne - Together, we elevate science to the next level of possibility. Also enhances the generation of induced pluripotent stem cells (iPSCs) from mouse and human somatic cells by increasing. IWP 2 suppresses self-renewal in R1 embryonic stem. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. 1 or Ca v 3. Biological Activity for Cisplatin. Scale bar. Used in experiments to understand biological processes and diseases. Unlike Bicuculline (Cat. Select a batch to recalculate based on the batch molecular. , a company that was founded in 1982 by Professor Jeff Watkins and Professor Richard Cookson to provide research tools and probes for glutamate receptors. PD 0325901 inhibits the growth of melanoma cell lines in vitro and in vivo; induces G 1 -phase cell cycle arrest and apoptosis in a mouse xenograft model. Add 10 l of the Cell Counting Kit-8 solution to each well of the plate. Clearance Sale. Activation of 2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. 275 864 PMID 7473178 Smith et al (2009) In vitro electrophysiological activity of nerispirdine,. rotowire nba, taurus 605 altamont grips
Rationally designed based on a ternary complex crystal structure to improve selectivity for BRD4 degradation compared to MZ1 (Cat. . Tocris
Biological Activity for D-Ala 2 -GIP (human) D-Ala 2 -GIP (human) is a highly potent GIP receptor agonist (EC 50 630 &177; 119 pM). Von der Leyen (1989) Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations. Available from Tocris Bioscience. Compounds supplied pre-dissolved in DMSO (100 L, 10 mM solution). Disturbances within the pathway may lead to the formation of tumors and promote metastasis. Fluorescent amine-reactive dye for labeling proteins, peptides and oligonucleotides. 2-Deoxy- D -glucose is a non-metabolizable glucose analog. Immediately before transfection, replace the HEK culture media with DMEM. A 83-01 is a potent inhibitor of TGF- type I receptor ALK5 kinase, type I activinnodal receptor ALK4 and type I nodal receptor ALK7 (IC 50 values are 12, 45 and 7. The amount required to prepare 1 ml of a 100 mM solution 14. mgmL Max Conc. N -Acetylcysteine amide improves neuronal mitochondrial bioenergetics, reduces tissue damage and enhances functional recovery following spinal cord injury in rats. SR 141716A is a potent and selective cannabinoid CB 1 receptor antagonist (K i 1. Preparing Stock Solutions for ()-Bicuculline. Biological Activity for 5-Fluorouracil. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a von Hippel-Lindau (VHL)-binding ligand. 06 and 6. Chemotherapeutic for the treatment of breast cancer; regulates Bax and Bcl-2 expression when administered. 08 and 7. to Tocris and has a low overlap with other commercially available compound libraries. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Also potent GPR55 agonist (EC 50 39 nM) and -opioid receptor antagonist (K 251 nM). 3 nM). Select a batch to recalculate based on the batch molecular weight. Preparing Stock Solutions for Carbamoylcholine chloride. Inactive against a panel of 37 other receptors at a concentration of 10 M. NHS ester can be converted to relevant substrate for use in self-labeling tag systems, e. Expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) after. Decreases levels of lysine 9 dimethylation on histone H3 (H3K9Me2) in PC3 cells. Promotes cardiomyocyte differentiation in. Poly (IC) also promotes maturation of hPSC-derived cardiomyocytes by modulating early Notch signaling and cardiomyogenic transcriptional programs. Upon ligand binding, the GPCR undergoes a conformational. Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and neurocytosis induced by excess stimulation by kainic acid. HaloTag &174; and SNAP-tag &174;. Tocris Bioscience is a supplier of small molecules, peptides, controlled substances, toxins, caged compounds, CRISPR reagents, DREADD ligands, and more for various research areas. Inhibits AMPK activation induced by AICAR (Cat. 7152) No. 15 M and 4. PD 0325901 inhibits the growth of melanoma cell lines in vitro and in vivo; induces G 1 -phase cell cycle arrest and apoptosis in a mouse xenograft model. Clozapine N-oxide dihydrochloride exhibits improved bioavailability (6 - 7-fold higher plasma concentration) compared with CNO, with less. Promotes cardiomyocyte differentiation in. 75 nM for rat and human receptors respectively). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKC , PKA and JAK3. Apoptosis 14 1070 PMID 25602147. Learn how to dilute a stock solution of known concentration using the Tocris dilution calculator, a tool that calculates the volume of a given solution based on the concentration and volume of the starting and final solutions. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. CGP 55845 hydrochloride is a potent, selective GABA B receptor antagonist (IC 50 5 nM) that prevents agonist binding (pK 8. 8 M, respectively). 1 nM, 5. Enhances radiation-induced tumor regression in nude mice bearing NSCLC xenografts. Example Applications of Clozapine N. Citations are publications that use Tocris products. 1 nM, 5. 2 channels (IC 50 6. PROTACs, also known as Active Degraders, consist of binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker. 0 M for cytotoxicity against mouse TLX5 lymphoma cells). Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (Cat. Biological Activity for SC 79. Induces potent and selective degradation of FKBP12 F36V fusion proteins in vitro and in vivo. Exhibits antiviral activity against viruses from Coronaviridae family including SARS-CoV-2 in vitro, and SARS. Decreases levels of lysine 9 dimethylation on histone H3 (H3K9Me2) in PC3 cells. Please note that Tocris will only send literature to established scientific business institute addresses. Customer service, shipping, technical support and order-related administrative activities are handled by Bio-Techne, or our distributor network. ICI 182,780 inhibits MCF-7 human breast cancer cell growth in vitro and shows antitumor activity in mice models. First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation. Touching a billon lives through innnovation. mgmL Max Conc. Phosphoramide mustard (active metabolite) forms DNA cross-links leading to cell death. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Tocris Products by Catalog Number. It promotes differentiation of mouse embryonic stem cells (ESCs) into adipocytes, neurons and glia in vitro. Tocris provides a range of fluorescent probes, including CoraFluor terbium cryptate FRET donors and fluorescent E3 ligase ligands, suitable for exploring ligand. 33 nM). 7 x 10 -3 g in 1 ml. View and buy high purity NMDA Receptor agonists from Tocris Bioscience. Save with limited-time price reductions across select products and categories. Torin 1 is a potent and selective ATP-competitive mTOR inhibitor (IC 50 2 - 10 nM for mTORC1 and mTORC2). The following data is based on the product molecular weight 298. Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60MX2, keratinocytes, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines. Save with limited-time price reductions across select products and categories. 3, 1. Biological Activity for SR 141716A. 35) and inhibits GABA and glutamate release (pEC 50 values are 8. The calculator is based on the formula C1V1 C2V2, where C1 and C2 are the starting and final concentrations, and V1 and V2 are the volumes of the starting and final solutions. Dihydro--erythroidine hydrobromide is a member of the Erythrina alkaloids, it is a competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal 4 receptor subunit (IC 50 values are 0. Acts as Wnt activator. The Tocris Scholarship Program has been established to award a 1,500 scholarship (or international currency equivalent) twice a year for the fall and spring semesters. NS 11021 is an activator of large-conductance Ca 2 -activated potassium channels (BK Ca, K Ca 1. Often defined as a multifactorial disease, with genetic, epigenetic and environmental factors influencing its progression, cancer usually develops over many decades from rela-. AGN 193109 is a high affinity pan-retinoic acid receptor (RAR) antagonist (K d values are 2, 2 and 3 nM at RAR , RAR and RAR , respectively). 8 nM for the CBP-bromodomain HAT-CH3 (BHC) and p300-BHC domains, respectively), which displays > 1000-fold selectivity over closely related HATs. 014 nM, respectively). Enhances radiation-induced tumor regression in nude mice bearing NSCLC xenografts. Tocris offers an unrivaled range of flexible, cost effective services via an expert team with a proven ability to deliver high purity products on time and on budget. LY 294002 hydrochloride is a prototypical PI 3-kinase inhibitor (IC 50 values are 0. 0100 0200 0300 0400 0500 0600 0700 0800 0900 1000 1100 1200 1300 1400 1500 1600 1700 1800 1900 2000 2100 2200 2300 2400 2500 2600 2700 2800 2900 3000 3100 3200 3300 3400 3500 3600 3700 3800 3900 4000 4100 4200 4300 4400 4500 4600 4700 4800 4900 5000 5100 5200 5300 5400 5500 5600. Demonstrates profound and selective degradation. The company was acquired by R&D Systems in 2011 and became part of Bio-Techne in 2016. Glycosaminoglycan that behaves as an anticoagulant. PEI STAR is a chemically-defined, high-performance polyethylenimine (PEI) transfection reagent for cost-effective, affordable and scalable transient gene expression. 76 M), leading to suppression of MAPK signaling and. Reconstitution Calculator. Depression Poster. Available from Tocris Bioscience. Find the products you need with fast shipping and reliable availability. I-BRD9 is a potent and selective BRD9 inhibitor (pIC 50 7. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service. Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKC , PKA and JAK3. Exhibits >50-fold selectivity for TBK1 over the closely related IKK. Torin 1 displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34. 85 respectively). We invite you to request or download your copy today. Therefore, although the purity of a particular peptide may be quoted as that of 98, the net peptide content may only be 70. Also inhibits TMEM16A channels (IC 50 2. IWP 2 inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Displays 500-fold selectivity for LAT1 over LAT2. Antagonizes behavioral effects of nicotine in vivo. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60MX2, keratinocytes, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines. Forskolin, or coleonol, is a cell-permeable, potent, reversible and rapid activator of adenylyl cyclase, an enzyme that converts ATP to cAMP and pyrophosphate (EC 50 0. 2 nM and 0. 6 nM). Facilitates differentiation of neural progenitor cells in vitro. Tocris kinase Inhibitors related products. Tocris offers an unrivaled range of flexible, cost effective services via an expert team with a proven ability to deliver high purity products on time and on budget. References are publications that support the biological activity of the product. Select a batch to recalculate based on the batch. CCCP is a protonophore. Two photon excitation spectra 780 nm; one photon absorptionemission spectra 348423 nm; Quantum yield 0. In germ cells from male mice, ()-JQ1 exhibits reversible contraceptive. 7163), Emricasan (Cat. More potent than SB 431542 (Cat. Also induces apoptosis in TRAIL-resistant glioma cells in vitro. Also an agonist at 5-HT 2C receptors in vitro (K values are 6. Kainic acid, also known as kainate, is a selective agonist of kainate ionotropic glutamate receptors (EC 50 0. Comprising binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker, these hybrid molecules induce selective, proteasome-dependent degradation of target proteins and can be used to. 13 M, 0. PROTACs, also known as Active Degraders, consist of binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker. The dTAG system, developed by Dr Behnam Nabet and colleagues at the Dana Farber Cancer Center, is a generalizable approach and a form of. . spsnk bang